Patients treated with injectable drug Repatha were 27 per cent less likely to have a heart attack and 21 per cent less likely to have a stroke over two years than if they had been taking statins alone. Inhibiting the protein can cause the level of LDL, or "bad" cholesterol, to tumble dramatically to unheard-of levels - from 92 milligrams per deciliter to 30 milligrams.
The worldwide team, which includes researchers from Imperial College London, says the drug could provide added benefit to patients already taking statins by further reducing the levels of low-density lipoprotein (LDL) cholesterol in their blood.
The UK section of the trial was organised by Imperial College London professor Peter Sever, with funding from the drug company Amgen.
The study mainly revolves around the severe major adverse cardiovascular event (MACE), which refers to events like first heart attack, strokes or cardiovascular death.
But that was based on early studies that showed the drug could merely reduce cholesterol and stop furring of arteries.
The study was conducted on 27,564 patients and almost 80 percent of them had suffered from a heart attack.
The study involved 27,564 men and women.
Although about 5% of patients in the clinical trial had a heart attack or stroke, rates of those problems could be two to three times higher in the real world, where patients are often older and sicker than those in clinical trials, Ofman said.
It means that if all 325,000 eligible Britons were to be treated, 2,200 potentially fatal heart emergencies would be avoided every year.
What Will Jim Parsons Role Be In The Big Bang Theory Spinoff
Jon Favreau, who directed various installments of The Avengers movie franchise and The Jungle Book , is leading the pilot episode. If the cast members' offer will be approved, the actress will receive $450,000 per episode in Seasons 11 and 12.
Poland's Kaczynski says EU on path towards disintegration
Polish Prime Minister Beata Szydlo had instead asked for all to support Jacek Saryusz-Wolski, a member of the European Parliament. Lithuanian President Dalia Grybauskaite said: "We don't want to become hostages of national politics inside Poland".
The treatments were approved only for specific groups - those with a genetic condition which means they have dangerously high cholesterol, and people with heart disease who can not cope with the side effects of statins.
Repatha and Praluent, which belong to a class called PCSK9 inhibitors, are especially expensive because they would be taken for such a long time.
Stubbornly high cholesterol is a key risk factor. Insurers largely use pharmacy benefits managers to set up the lists that determine how much a patient ends up paying. But some people can not take them without significant side effects such as muscle pain, and in most people they do not lower LDL cholesterol as significantly as the new drugs. The results have also been published in the New England Journal of Medicine. Many doctors wondered if such low levels would be risky, causing memory problems or dementia due to a lack of cholesterol, said Dr. Steven Nissen, chair of cardiovascular medicine at the Cleveland Clinic, who was not involved in the new research but has led clinical trials of PCSK9 inhibitors in the past.
"A promising new approach is blocking the action of PCSK9, a molecule which reduces the breakdown of LDL-cholesterol in the liver".
Sabatine said he would like to see Repatha tested in other high-risk patients, such as those with type 2 diabetes, which could substantially increase the market.
The standard treatment for cholesterol, other than diet and exercise, is a generic statin, which costs $250 a year.
Dr. Donald Lloyd-Jones, preventive medicine chief at Northwestern University and an American Heart Association spokesman, called the results modest and "not quite what we hoped or expected". For now, "we should still probably reserve these for the highest risk patients where statins are not doing a good enough job - at least at the price they are currently offered", said Lloyd-Jones.
British Heart Foundation medical director Nilesh Samani said the trial was a significant advance. However, there are some deus which are prescribed to the patients with high levels of cholesterol but the cost of some them are really high.
The projected first-round draft pick had an air cast placed on his left leg as he was taken out of the practice facility. Reports say that Jones fell to the ground during a back pedal drill and had to be helped off the field.
Officials attend a ceremony held beside the Airbus A330-200 after it touched down at Mehrabad Airport in Tehran. The first Airbus A321 purchased from the European giant had been delivered to Iran Air earlier on January 12.
WEST BROM: Foster 5, Dawson 6, McAuley 6, Evans 5, Nyom 4, Livermore 5, Yacob 5, Fletcher 5, Chadli 5, McClean 4, Robson-Kanu 5. Lukaku finally got his name on the score sheet heading in Ross Barkley's cross from close range in the 83rd minute.
Retno added that in the next two months, the President would he send a minister to follow up King Salman's visit to Indonesia. Bilateral trade in 2015 was worth almost $40 billion, with India importing a fifth of its oil needs from Saudi Arabia.
He's used to dating entertainment A-listers, having previously been linked to Madonna, Kate Hudson and Cameron Diaz. I still can't stand A-Rod and the fact that he posed topless on a rock and posted it on social media.
In a separate statement, Sprint said its agreement with Radio Shack was created to protect it in the event of another bankruptcy. The chain dealing in electronics in the United States, RadioShack Corp has filed for bankruptcy on Wednesday.
However, some observers questioned whether her business credentials were sufficient to earn her a place at the meeting. The meeting has been highly anticipated as the two leaders have publicly differed on key issues.
Cannon-Brookes tweeted both Weatherill and Musk with the same message: "Not to push my luck ... big $ commitments pouring in". Sarah Hanson-Young, an Australian senator, said on Twitter on Friday that she wanted to talk to Musk about his offer.
Sanders, 28, spent his first five seasons with the Milwaukee Bucks, averaging 6.5 points, 5.8 rebounds and 1.8 blocks per game. Cleveland has played with just two bigs since Love's injury - Tristan Thompson and Channing Frye - save for Bogut's 58 seconds.
Erdogan: Netherlands Acting like a 'banana republic'
Separately, Finance Minister Wolfgang Schaeuble said Turkey had "destroyed the basis for further progress in co-operation". A Turkish protester had scaled the wall, replaced the Dutch colours, and shouted that God was great.
Polish president congratulates Tusk in letter
On Thursday, Tusk was reelected as the president of the European Council despite Poland's determination to postpone the vote. She added the European Council served a narrow set of countries, in a thinly veiled reference to Germany.
Google machine learning gains Kaggle and more
The keynote was about Google's serious commitment to being a player in the emerging game of cloud-based services and platforms. For more information on Google's new products and developments, visit Google Cloud's Big Data and Machine Learning Blog.
30 die in Myanmar-China border town
The owner of another hotel, calling himself by his surname Yang, said: "All we can do is to help them and give them food". The military said it recovered 20 charred bodies it says belonged to fallen insurgents.