Patients treated with injectable drug Repatha were 27 per cent less likely to have a heart attack and 21 per cent less likely to have a stroke over two years than if they had been taking statins alone. Inhibiting the protein can cause the level of LDL, or "bad" cholesterol, to tumble dramatically to unheard-of levels - from 92 milligrams per deciliter to 30 milligrams.
The worldwide team, which includes researchers from Imperial College London, says the drug could provide added benefit to patients already taking statins by further reducing the levels of low-density lipoprotein (LDL) cholesterol in their blood.
The UK section of the trial was organised by Imperial College London professor Peter Sever, with funding from the drug company Amgen.
The study mainly revolves around the severe major adverse cardiovascular event (MACE), which refers to events like first heart attack, strokes or cardiovascular death.
But that was based on early studies that showed the drug could merely reduce cholesterol and stop furring of arteries.
The study was conducted on 27,564 patients and almost 80 percent of them had suffered from a heart attack.
The study involved 27,564 men and women.
Although about 5% of patients in the clinical trial had a heart attack or stroke, rates of those problems could be two to three times higher in the real world, where patients are often older and sicker than those in clinical trials, Ofman said.
It means that if all 325,000 eligible Britons were to be treated, 2,200 potentially fatal heart emergencies would be avoided every year.
Starbucks' new spring cups look awfully like Twitter eggs
According to Starbucks , cups also include hand-drawn designs of appropriately spring-themed objects like umbrellas and the sun. - amber whitten (@ambersometimez) March 9, 2017 @ Starbucksnews @Starbucks I ❤️ the new #SpringCups ...
Polish president congratulates Tusk in letter
On Thursday, Tusk was reelected as the president of the European Council despite Poland's determination to postpone the vote. She added the European Council served a narrow set of countries, in a thinly veiled reference to Germany.
The treatments were approved only for specific groups - those with a genetic condition which means they have dangerously high cholesterol, and people with heart disease who can not cope with the side effects of statins.
Repatha and Praluent, which belong to a class called PCSK9 inhibitors, are especially expensive because they would be taken for such a long time.
Stubbornly high cholesterol is a key risk factor. Insurers largely use pharmacy benefits managers to set up the lists that determine how much a patient ends up paying. But some people can not take them without significant side effects such as muscle pain, and in most people they do not lower LDL cholesterol as significantly as the new drugs. The results have also been published in the New England Journal of Medicine. Many doctors wondered if such low levels would be risky, causing memory problems or dementia due to a lack of cholesterol, said Dr. Steven Nissen, chair of cardiovascular medicine at the Cleveland Clinic, who was not involved in the new research but has led clinical trials of PCSK9 inhibitors in the past.
"A promising new approach is blocking the action of PCSK9, a molecule which reduces the breakdown of LDL-cholesterol in the liver".
Sabatine said he would like to see Repatha tested in other high-risk patients, such as those with type 2 diabetes, which could substantially increase the market.
The standard treatment for cholesterol, other than diet and exercise, is a generic statin, which costs $250 a year.
Dr. Donald Lloyd-Jones, preventive medicine chief at Northwestern University and an American Heart Association spokesman, called the results modest and "not quite what we hoped or expected". For now, "we should still probably reserve these for the highest risk patients where statins are not doing a good enough job - at least at the price they are currently offered", said Lloyd-Jones.
British Heart Foundation medical director Nilesh Samani said the trial was a significant advance. However, there are some deus which are prescribed to the patients with high levels of cholesterol but the cost of some them are really high.
This is the main reason why Nintendo has recently made a decision to double the production for their much appreciated console. The 3DS portable system, meanwhile, has sold over 65 million units since its launch in early 2012.
Sturgeon made her dramatic announcement at a hastily-arranged press conference at her official residence in Bute House, Edinburgh. Sturgeon's decision comes after Brexit, a close UK-wide referendum in which citizens voted to leave the European Union.
Separately, Finance Minister Wolfgang Schaeuble said Turkey had "destroyed the basis for further progress in co-operation". A Turkish protester had scaled the wall, replaced the Dutch colours, and shouted that God was great.
The keynote was about Google's serious commitment to being a player in the emerging game of cloud-based services and platforms. For more information on Google's new products and developments, visit Google Cloud's Big Data and Machine Learning Blog.
He's used to dating entertainment A-listers, having previously been linked to Madonna, Kate Hudson and Cameron Diaz. I still can't stand A-Rod and the fact that he posed topless on a rock and posted it on social media.
A source told Page Six on March 8: " They have been seeing each other for a few weeks, and were together in LA this past weekend". Apparently Jennifer Lopez has finally revealed that her and the 6 God were not in a real relationship.
The role of Solicitor General doesn't usually make too many headlines, but that's nearly certain to change in the next four years. Francisco was also a White House lawyer from 2001 to 2003, and legal counsel for the Justice Department from 2003 to 2005.
He was not included in the annual January camp for domestic players. "Jones is a different situation", said Arena. Forwards Clint Dempsey and Jordan Morris have been named to Bruce Arena's roster for the U.S.
The Ontario Provincial Police indicated that the pile-up involved cars and about a dozen trucks, including heavy goods vehicles. At least 10 of the patients were first responders, who underwent decontamination and were held for observation as a precaution.
Professor Kelly and family tackle viral #BBCDad video
The Journal noted that the video had been viewed over 84 million times on the BBC Facebook page as of Tuesday morning. Kelly's wife along with their four-year-old daughter and their nine-month-old son also attended the news conference.
Japan's Abe, Saudi king see eye to eye on Vision 2030
Retno added that in the next two months, the President would he send a minister to follow up King Salman's visit to Indonesia. Bilateral trade in 2015 was worth almost $40 billion, with India importing a fifth of its oil needs from Saudi Arabia.
Washington's Sidney Jones injures left leg in workouts
The projected first-round draft pick had an air cast placed on his left leg as he was taken out of the practice facility. Reports say that Jones fell to the ground during a back pedal drill and had to be helped off the field.
Tesla humiliates Do-nothing Australian government
Cannon-Brookes tweeted both Weatherill and Musk with the same message: "Not to push my luck ... big $ commitments pouring in". Sarah Hanson-Young, an Australian senator, said on Twitter on Friday that she wanted to talk to Musk about his offer.
Los Angeles fault could cause 7.4-magnitude quake
The coast of Southern California and Tijuana, Mexico are highly vulnerable to the fault, the report indicated. The connections - or stepovers - between the main parts of the faults are less than 2Km wide.
Mourinho fumes at Rostov pitch
Manchester United gave as good as they got in the challenges and were victims of some bad play acting as well by Rostov . Also the fact that they are used to playing on that pitch, and United are not, might give them a slight advantage.
Poland's Kaczynski says EU on path towards disintegration
Polish Prime Minister Beata Szydlo had instead asked for all to support Jacek Saryusz-Wolski, a member of the European Parliament. Lithuanian President Dalia Grybauskaite said: "We don't want to become hostages of national politics inside Poland".